Jean M. Mukherjee, DVM, PhD, DACVMAssistant Professor, Vaccines, Infectious Diseases, Department of Infectious Disease and Global Health
Cummings School of Veterinary Medicine 508-887-4756
I am a faculty member at Tufts Veterinary School with a dual background in veterinary medicine and infectious diseases. I have extensive experience with animal model development, in vivo evaluation of candidate therapeutics against infectious and toxin-mediated disease and development of monoclonal antibodies (mAbs). I currently manage a Select Agent Facility that supports both in vivo and in vitro work with botulinum toxin (BoNT). My group has been responsible for establishment and conduct of both the mouse lethality and mouse/rat hindlimb paresis assays for multiple BoNT toxinotypes. We have used these assays extensively for evaluation of candidate biological and small-drug inhibitor molecules. Other models of infectious or toxin-mediated disease that I have utilized include: Murine models of cryptococcosis (intraperitoneal, intravenous, intrathecal, intratracheal); murine models of Shiga toxin activity; the EHEC gnotobiotic piglet model; the Clostridium difficile hamster model; and the murine thigh infection model for evaluation of candidate therapeutics against bacterial pathogens.